Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 11/20 | 0.68 |
| ▸ | KDR | P35968 | 11/20 | 0.68 |
| ▸ | AXL | P30530 | 4/20 | 0.68 |
| ▸ | FLT3 | P36888 | 2/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.68 |
| ▸ | MST1R | Q04912 | 11/20 | 0.52 |
| ▸ | MERTK | Q12866 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | ABL2 | P42684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16660507 | 0.91 | MET (0.56) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL15808524 | 0.88 | MET (0.51) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL2531006 | 0.87 | MET (0.52) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL106728 | 0.87 | MET (0.70) | METKDRAXLFLT3MST1R | |
| SCHEMBL15808515 | 0.87 | MET (0.52) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL105450 | 0.85 | MET (0.77) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1478762 | 0.85 | MET (0.49) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1481549 | 0.84 | MET (0.49) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL106737 | 0.84 | MET (0.45) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL21760402 | 0.84 | MET (0.86) | METKDRAXLFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018378-B2 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC. (CA) | 2015-04-28 | — | — | US | disclosed |