Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109276 | 0.76 | KCNA5 (0.35) | KCNA5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL16660453 | 0.74 | HDAC3 (0.34) | HDAC1HDAC6MEN1KMT2A | |
| SCHEMBL4835409 | 0.69 | IRAK4 (0.40) | IRAK4HTR7KCNA5CHRNB2CHRNA4 | |
| SCHEMBL107426 | 0.69 | HDAC1 (0.41) | HTR7CHRNB2CHRNA4ALDH1A1HPGD | |
| SCHEMBL988506 | 0.68 | IRAK4 (0.41) | IRAK4HTR7CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL31598824 | 0.65 | HTR7 (0.47) | HTR7CHRNB2CHRNA4ALDH1A1KCNQ3 | |
| SCHEMBL67946 | 0.65 | IRAK4 (0.39) | IRAK4CHRNB2CHRNA4ALDH1A1HPGD | |
| SCHEMBL17440911 | 0.65 | IRAK4 (0.41) | IRAK4HTR7CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL2768666 | 0.64 | MAPT (0.39) | IRAK4ALDH1A1HPGDHDAC1SMN1; SMN2 | |
| SCHEMBL171494 | 0.64 | SSTR4 (0.42) | HTR7CHRNB2CHRNA4ALDH1A1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9018378-B2 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | METHYLGENE INC. (CA) | 2015-04-28 | — | — | US | disclosed |