Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20461926 | 0.83 | PIK3CD (0.43) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12573383 | 0.82 | PIK3CA (0.54) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19286558 | 0.81 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13983303 | 0.81 | PIK3CG (0.65) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL116324 | 0.81 | PIK3CA (0.56) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20461995 | 0.81 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29556703 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL114826 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL25688980 | 0.79 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| Ammonia Solution, Strong SCHEMBL28553362 | 0.79 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3053926-B1 | FUSED PYRIMIDINE COMPOUND, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND COMPOSITION AND APPLICATION THEREOF | SHANGHAI YINGLI PHARM CO LTD (CN) | 2018-08-08 | — | — | EP | disclosed |
| WO-2016193255-A1 | PROCESSES TO MAKE INDAZOLE DERIVATIVES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-12-08 | — | — | WO | disclosed |
| WO-2015055690-A1 | PI3K INHIBITOR FOR TREATMENT OF RESPIRATORY DISEASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015055691-A1 | PI3K INHIBITOR FOR TREATMENT OF RESPIRATORY DISEASE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-04-23 | — | — | WO | disclosed |