Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20234029 | 0.86 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20234037 | 0.84 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16660718 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL20921440 | 0.80 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12573383 | 0.80 | PIK3CA (0.54) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL18857350 | 0.79 | ALDH1A1 (0.33) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22914723 | 0.78 | PIK3CA (0.57) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL116324 | 0.78 | PIK3CA (0.56) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL114826 | 0.78 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29556703 | 0.78 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10842791-B2 | Small molecule inhibitors of EGFR and PI3K | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-11-24 | — | — | US | disclosed |
| US-20190167686-A1 | SMALL MOLECULE INHIBITORS OF EGFR AND PI3K | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2019-06-06 | — | — | US | disclosed |
| US-10266525-B2 | Processes for preparing 2-(6-(1H-indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-04-23 | — | — | US | disclosed |
| US-20180155334-A1 | NOVEL PROCESSES | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-06-07 | — | — | US | disclosed |
| US-9745321-B2 | Fused pyrimidine compound, intermediate, preparation method therefor, and composition and application thereof | SHANGHAI YINGLI PHARMACEUTICAL CO., LTD (CN) | 2017-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155334-A1 | NOVEL PROCESSES | CYP4A11, CYP4F11, CYP4F3 | PIK3CD 758/4885PIK3CA 677/4885PIK3CB 885/4885 |
| US-10842791-B2 | Small molecule inhibitors of EGFR and PI3K | EGFR, ERBB2, ERBB3 | PIK3CD 8/4885PIK3CA 6/4885PIK3CB 16/4885 |
| US-20190167686-A1 | SMALL MOLECULE INHIBITORS OF EGFR AND PI3K | EGFR, ERBB2, ERBB3 | PIK3CD 8/4885PIK3CA 6/4885PIK3CB 16/4885 |
| US-10266525-B2 | Processes for preparing 2-(6-(1H-indol-4-yl)-1H-indazol-4-yl)-5-((4-isopropylpiperazin-1-yl)methyl)oxazole | IPO4, CYP3A4, CYP4B1 | PIK3CD 700/4885PIK3CA 682/4885PIK3CB 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.