Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.42 |
| ▸ | ASPH | Q12797 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 5/20 | 0.35 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992595 | 0.86 | SIRT6 (0.44) | SIRT6ASPHKDM4EHCAR2NAPRT | |
| SCHEMBL29005159 | 0.83 | SIRT6 (0.42) | SIRT6ASPHKDM4EHCAR2NAPRT | |
| SCHEMBL9947622 | 0.79 | SIRT6 (0.49) | SIRT6KDM4EHCAR2NAPRTP4HTM | |
| SCHEMBL2645887 | 0.76 | SIRT6 (0.50) | SIRT6ASPHKDM4EHCAR2NAPRT | |
| SCHEMBL936961 | 0.76 | SIRT6 (0.42) | SIRT6ASPHKDM4EHCAR2NAPRT | |
| SCHEMBL18401863 | 0.76 | SIRT6 (0.42) | SIRT6ASPHKDM4EL3MBTL1MAPK1 | |
| SCHEMBL17495670 | 0.76 | SIRT6 (0.42) | SIRT6ASPHKDM4EL3MBTL1MAPK1 | |
| Hydrochloric Acid SCHEMBL17668830 | 0.75 | SIRT6 (0.41) | SIRT6ASPHKDM4EHCAR2NAPRT | |
| SCHEMBL991368 | 0.73 | SIRT6 (0.46) | SIRT6ASPHKDM4EHCAR2NAPRT | |
| SCHEMBL31379016 | 0.73 | SIRT6 (0.46) | SIRT6ASPHKDM4EHCAR2NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332943-B1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2015-04-22 | — | — | EP | disclosed |