Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 17/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.38 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | PDE6D | O43924 | 2/20 | 0.38 |
| ▸ | PDE8A | O60658 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | PDE8B | O95263 | 2/20 | 0.38 |
| ▸ | PDE6A | P16499 | 2/20 | 0.38 |
| ▸ | PDE6G | P18545 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE6B | P35913 | 2/20 | 0.38 |
| ▸ | PDE6C | P51160 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 2/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13240958 | 1.00 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| SCHEMBL16649302 | 1.00 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| Bromide SCHEMBL2484946 | 0.99 | CHRM3 (0.46) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| SCHEMBL13241017 | 0.96 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| SCHEMBL16020786 | 0.96 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| Bromide SCHEMBL2482110 | 0.96 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| SCHEMBL16664430 | 0.95 | CHRM3 (0.41) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| SCHEMBL13240977 | 0.95 | CHRM3 (0.41) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| Bromide SCHEMBL2485675 | 0.95 | CHRM3 (0.43) | CHRM3CHRM2CHRM1PDE2APDE6D | |
| SCHEMBL13282528 | 0.94 | CHRM3 (0.47) | CHRM3CHRM2CHRM1PDE2APDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376489-B1 | ALKALOID AMINOESTER DERIVATIVES AND MEDICINAL COMPOSITION THEREOF | CHIESI FARMA SPA (IT) | 2015-04-22 | — | — | EP | disclosed |