⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8352324 | 0.79 | — | — | |
| SCHEMBL10881736 | 0.74 | MAPT (0.44) | — | |
| SCHEMBL2723133 | 0.72 | — | — | |
| SCHEMBL1072436 | 0.72 | — | — | |
| SCHEMBL1072438 | 0.72 | — | — | |
| SCHEMBL4404716 | 0.72 | — | — | |
| SCHEMBL23355973 | 0.70 | — | — | |
| SCHEMBL11795310 | 0.70 | — | — | |
| Ammonia Solution, Strong SCHEMBL11799624 | 0.70 | — | — | |
| SCHEMBL11329037 | 0.66 | MAPT (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9539256-B2 | Modulators of exchange proteins directly activated by cAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-01-10 | — | — | US | disclosed |
| US-20150110809-A1 | MODULATORS OF EXCHANGE PROTEINS DIRECTLY ACTIVATED BY CAMP (EPACS) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-04-23 | — | — | US | disclosed |
| US-7790723-B2 | Thiazole derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| US-7790723-B2 | Thiazole derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| EP-1511737-B1 | ARYLOXIMES | MERCK PATENT GMBH (DE) | 2010-02-17 | — | — | EP | disclosed |
| EP-1509506-B1 | PYRIDAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-7563790-B2 | Pyridazine derivatives | MERCK PATENT GMBH (DE) | 2009-07-21 | — | — | US | disclosed |
| US-7563790-B2 | Pyridazine derivatives | MERCK PATENT GMBH (DE) | 2009-07-21 | — | — | US | disclosed |
| US-7470687-B2 | Aryl oximes | MERCK PATENT GMBH (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470687-B2 | Aryl oximes | MERCK PATENT GMBH (DE) | 2008-12-30 | — | — | US | disclosed |
| WO-2003104205-A1 | ARYLOXIMES | MERCK PATENT GMBH (DE) | 2003-12-18 | — | — | WO | disclosed |