Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343048 | 1.00 | KDM4E (0.47) | KDM4EMAPTMAPK1POLBHCAR3 | |
| SCHEMBL15356477 | 0.93 | KIT (0.50) | KDM4EMAPTMAPK1POLBHCAR3 | |
| SCHEMBL16660259 | 0.87 | KDM4E (0.52) | KDM4EMAPTMAPK1POLBHCAR3 | |
| SCHEMBL15342983 | 0.87 | KDM4E (0.57) | KDM4EMAPTMAPK1POLBKIT | |
| SCHEMBL15343309 | 0.84 | HCAR3 (0.47) | KDM4EMAPTMAPK1POLBHCAR3 | |
| SCHEMBL16664919 | 0.83 | PIK3CA (0.44) | KDM4EMAPTMAPK1POLBHCAR3 | |
| SCHEMBL15343392 | 0.82 | KIT (0.42) | KDM4EMAPTMAPK1POLBHCAR3 | |
| SCHEMBL15343345 | 0.81 | CYP1A2 (0.53) | KDM4EMAPTMAPK1HPGDSMN1; SMN2 | |
| SCHEMBL16665002 | 0.81 | PIK3CA (0.45) | KDM4EMAPTMAPK1POLBHPGD | |
| SCHEMBL16664966 | 0.81 | CYP1A2 (0.47) | KDM4EMAPTMAPK1POLBHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |