Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 12/20 | 0.50 |
| ▸ | PRKDC | P78527 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874672 | 1.00 | FAAH (0.50) | FAAHPRKDCCYP1A2MAPK1CYP2C19 | |
| SCHEMBL19905489 | 0.90 | FAAH (0.48) | FAAHPRKDCCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL17634698 | 0.88 | PRKDC (0.49) | FAAHPRKDCCYP1A2MAPK1CYP2C19 | |
| SCHEMBL17874676 | 0.86 | ABL1 (0.41) | FAAHPRKDCCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL15328500 | 0.86 | PRKDC (0.49) | FAAHPRKDCCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL15328493 | 0.86 | PRKDC (0.49) | FAAHPRKDCCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL15473073 | 0.85 | PRKDC (0.47) | FAAHPRKDC | |
| SCHEMBL17874671 | 0.85 | PRKDC (0.47) | FAAHPRKDC | |
| SCHEMBL17634923 | 0.85 | PRKDC (0.58) | FAAHPRKDCCYP1A2CYP2C19HSD17B10 | |
| SCHEMBL17874673 | 0.84 | PRKDC (0.46) | FAAHPRKDCCYP1A2CLK4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058031-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-23 | — | — | WO | disclosed |