Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 16/20 | 0.47 |
| ▸ | CDK9 | P50750 | 16/20 | 0.47 |
| ▸ | CDK7 | P50613 | 15/20 | 0.47 |
| ▸ | CCNH | P51946 | 15/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 13/20 | 0.47 |
| ▸ | CCNK | O75909 | 13/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 13/20 | 0.42 |
| ▸ | CDK2 | P24941 | 10/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.41 |
| ▸ | CDK13 | Q14004 | 5/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665168 | 0.93 | CDK7 (0.55) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL18069831 | 0.93 | CDK7 (0.55) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL23336346 | 0.93 | CDK7 (0.55) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16665153 | 0.83 | CDK7 (0.50) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16665107 | 0.82 | CDK7 (0.48) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL18069836 | 0.82 | CDK7 (0.48) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL18069834 | 0.80 | CDK7 (0.42) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL16665109 | 0.80 | CDK7 (0.42) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL18047277 | 0.77 | CDK7 (0.49) | CCNT1CDK9CDK7CCNHMNAT1 | |
| SCHEMBL18047288 | 0.77 | CDK7 (0.38) | CCNT1CDK9CDK7CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058140-A1 | POLYCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-04-23 | — | — | WO | disclosed |