Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 15/20 | 0.50 |
| ▸ | CCNH | P51946 | 15/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.50 |
| ▸ | CDK9 | P50750 | 15/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 13/20 | 0.50 |
| ▸ | CCNK | O75909 | 13/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 13/20 | 0.48 |
| ▸ | CDK2 | P24941 | 10/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.45 |
| ▸ | CDK13 | Q14004 | 4/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16655065 | 0.91 | CDK7 (0.59) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL18069838 | 0.91 | CDK7 (0.59) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL23336347 | 0.91 | CDK7 (0.59) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL16665144 | 0.83 | CCNT1 (0.47) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL20416156 | 0.83 | CDK7 (0.55) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL16665167 | 0.79 | CDK7 (0.62) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL18069831 | 0.76 | CDK7 (0.55) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL16665168 | 0.76 | CDK7 (0.55) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL23336346 | 0.76 | CDK7 (0.55) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL19600368 | 0.75 | CCNK (0.58) | CDK7CCNHCCNT1CDK9MNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058140-A1 | POLYCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-04-23 | — | — | WO | disclosed |