Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 18/20 | 0.92 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.92 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.92 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| H3B-6527 SCHEMBL30274661 | 0.96 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL29412748 | 0.96 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL16659467 | 0.96 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL18153616 | 0.95 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30070306 | 0.95 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL18153614 | 0.95 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| H3B-6527 SCHEMBL30070526 | 0.95 | FGFR1 (0.99) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16665263 | 0.95 | FGFR1 (0.88) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16659435 | 0.94 | FGFR1 (0.92) | FGFR1FGFR4FGFR2FGFR3 | |
| SCHEMBL16659479 | 0.93 | FGFR4 (1.00) | FGFR1FGFR4FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015057963-A1 | FGFR4 INHIBITORS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-23 | — | — | WO | disclosed |