Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.45 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | CDK7 | P50613 | 4/20 | 0.45 |
| ▸ | CCNH | P51946 | 4/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.45 |
| ▸ | CCNK | O75909 | 3/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 11/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 11/20 | 0.44 |
| ▸ | JUN | P05412 | 10/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30449686 | 0.80 | CDK2 (0.67) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL22977514 | 0.80 | CDK2 (0.67) | CDK2CCNE1CCNT1CDK9CDK1 | |
| SCHEMBL16665659 | 0.79 | IKBKB (0.45) | CDK2CCNE1CCNT1CDK9CDK7 | |
| SCHEMBL16665600 | 0.78 | MAPK8 (0.53) | CDK2CCNE1CCNT1MAPK8MAPK9 | |
| SCHEMBL16655034 | 0.70 | CCNK (0.67) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL16655035 | 0.70 | CCNK (0.67) | CDK2CCNT1CDK9CDK7CCNH | |
| SCHEMBL22977380 | 0.67 | CCNE1 (0.60) | CDK2CCNE1CCNT1CDK9CDK7 | |
| SCHEMBL23001306 | 0.67 | CCNE1 (0.49) | CDK2CCNE1CCNT1CDK9CDK7 | |
| SCHEMBL22997626 | 0.67 | CDK2 (0.42) | CDK2CCNE1CCNT1CDK9CDK7 | |
| SCHEMBL22997623 | 0.67 | CDK2 (0.53) | CDK2CCNE1CCNT1CDK9CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058163-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-04-23 | — | — | WO | disclosed |