Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 18/20 | 0.49 |
| ▸ | CDK2 | P24941 | 18/20 | 0.49 |
| ▸ | CDK1 | P06493 | 10/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.43 |
| ▸ | CDK4 | P11802 | 9/20 | 0.43 |
| ▸ | CCND1 | P24385 | 9/20 | 0.43 |
| ▸ | CCND3 | P30281 | 9/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.41 |
| ▸ | CDK9 | P50750 | 8/20 | 0.41 |
| ▸ | CDK7 | P50613 | 5/20 | 0.41 |
| ▸ | CCNH | P51946 | 5/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | CCNK | O75909 | 5/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22997623 | 0.89 | CDK2 (0.53) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22977380 | 0.85 | CCNE1 (0.60) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22997713 | 0.83 | CCNE1 (0.49) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL29820627 | 0.82 | CCNE1 (0.72) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22977357 | 0.82 | CCNE1 (0.72) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22983953 | 0.80 | CCNE1 (0.50) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22977485 | 0.80 | ULK1 (0.47) | CCNE1CDK2CCNT1CDK9CDK7 | |
| SCHEMBL22977432 | 0.80 | CCNE1 (0.58) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22997719 | 0.79 | CCNE1 (0.47) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL26268376 | 0.79 | CDK2 (0.45) | CCNE1CDK2CDK1CCNB1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021030537-A1 | IMIDAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION (US) | 2021-02-18 | — | — | WO | disclosed |