Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 5/20 | 0.38 |
| ▸ | ITK | Q08881 | 2/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | HCK | P08631 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.38 |
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665788 | 0.91 | SRC (0.42) | JAK3SRCJAK1MAP2K7AURKA | |
| SCHEMBL23917549 | 0.79 | SRC (0.59) | JAK3SRCAURKABTKITK | |
| SCHEMBL16665792 | 0.79 | SRC (0.45) | JAK3SRCJAK1MAP2K7AURKA | |
| SCHEMBL21467053 | 0.78 | PIK3CG (0.52) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL16665742 | 0.76 | PIK3CG (0.41) | SRCEGFRPIK3CDABL1HCK | |
| SCHEMBL9010 | 0.75 | PIK3CG (0.54) | SRCBTKEGFRPIK3CDABL1 | |
| SCHEMBL23917271 | 0.75 | BTK (0.40) | JAK3SRCBTKITKEGFR | |
| SCHEMBL21467104 | 0.73 | PIK3CD (0.54) | SRCBTKEGFRPIK3CDABL1 | |
| SCHEMBL11928101 | 0.73 | PIK3CD (0.56) | SRCBTKEGFRPIK3CDABL1 | |
| SCHEMBL16665803 | 0.73 | PIK3CD (0.57) | SRCBTKEGFRPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015058084-A1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-04-23 | — | — | WO | disclosed |