Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.60 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 6/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 7/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667673 | 1.00 | CXCR2 (0.60) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL4414662 | 0.82 | CXCR2 (0.66) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL252024 | 0.82 | CXCR2 (0.66) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL1345636 | 0.82 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL1820095 | 0.82 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL245190 | 0.82 | CXCR2 (0.69) | CXCR2CXCR1 | |
| SCHEMBL4747670 | 0.80 | CXCR2 (0.66) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL246051 | 0.80 | CXCR2 (0.66) | CXCR2CXCR1CA2CA1CA9 | |
| SCHEMBL1821726 | 0.79 | CXCR2 (0.61) | CXCR2CXCR1STSDRD2DRD1 | |
| SCHEMBL28065258 | 0.79 | CXCR2 (0.69) | CXCR2CXCR1CA2CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2485723-A1 | INHIBITORS OF CXCR1/2 AS ADJUVANTS IN THE TRANSPLANT OF PANCREATIC ISLETS | Dompé S.p.A. (IT) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011042466-A1 | INHIBITORS OF CXCR1/2 AS ADJUVANTS IN THE TRANSPLANT OF PANCREATIC ISLETS | Dompé S.p.A. (IT) | 2011-04-14 | — | — | WO | disclosed |