Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.66 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.36 |
| ▸ | CDC42 | P60953 | 1/20 | 0.36 |
| ▸ | RAC1 | P63000 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414662 | 1.00 | CXCR2 (0.66) | CXCR2CXCR1EPHX1CA1CA2 | |
| SCHEMBL28065260 | 0.96 | CXCR2 (0.69) | CXCR2CXCR1EPHX1CA1CA2 | |
| SCHEMBL28065258 | 0.96 | CXCR2 (0.69) | CXCR2CXCR1EPHX1CA1CA2 | |
| SCHEMBL245190 | 0.87 | CXCR2 (0.69) | CXCR2CXCR1APPPTGS2PTGS1 | |
| SCHEMBL1820095 | 0.87 | CXCR2 (0.69) | CXCR2CXCR1APPPTGS2PTGS1 | |
| SCHEMBL1345636 | 0.87 | CXCR2 (0.69) | CXCR2CXCR1APPPTGS2PTGS1 | |
| SCHEMBL13460874 | 0.86 | CXCR2 (0.60) | CXCR2CXCR1EPHX1CA1CA2 | |
| SCHEMBL2338983 | 0.86 | CXCR2 (0.60) | CXCR2CXCR1EPHX1CA1CA2 | |
| SCHEMBL2338978 | 0.86 | CXCR2 (0.60) | CXCR2CXCR1EPHX1CA1CA2 | |
| Hydrochloric Acid SCHEMBL2339186 | 0.85 | CXCR2 (0.59) | CXCR2CXCR1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250161248-A1 | Treating Chronic Myelomonocytic Leukemia with CXCL8 Receptor Inhibitors | INSTITUT GUSTAVE ROUSSY (FR) | 2025-05-22 | — | — | US | claimed |
| CN-119662091-A | Magnesium alloy high pressure resistance surface treatment liquid and preparation method thereof | 合肥华清高科表面技术股份有限公司 | 2025-03-21 | — | — | CN | claimed |
| US-20230310479-A1 | LOW DOSE ADJUVANT EPIGENETIC CANCER THERAPY | UNIV JOHNS HOPKINS (US) | 2023-10-05 | — | — | US | claimed |
| EP-4140486-A1 | METHODS AND COMPOUNDS FOR THE ALLEVIATION AND/OR PREVENTION OF PAIN | Klareskog, Lars (SE) | 2023-03-01 | — | — | EP | claimed |
| EP-3316886-B1 | METHODS AND COMPOUNDS FOR THE ALLEVIATION AND/OR PREVENTION OF PAIN | SVENSSON CAMILLA (SE) | 2022-05-18 | — | — | EP | claimed |
| US-10940126-B2 | Inhibition of IL-8 in the treatment of pain and/or bone loss | SVENSSON CAMILLA (SE) | 2021-03-09 | — | — | US | claimed |
| EP-3630104-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS | Dompé farmaceutici S.p.A. (IT) | 2020-04-08 | — | — | EP | claimed |
| US-20200101046-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2020-04-02 | — | — | US | claimed |
| US-20190248876-A1 | CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS | UNIV NEW YORK (US) | 2019-08-15 | — | — | US | claimed |
| WO-2018219865-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS | DOMPE' FARMACEUTICI S.P.A. (IT) | 2018-12-06 | — | — | WO | claimed |
| EP-3409277-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS | Dompé farmaceutici s.p.a. (IT) | 2018-12-05 | — | — | EP | claimed |
| US-20170181987-A1 | INHIBITION OF IL-8 IN THE TREATMENT OF PAIN AND/OR BONE LOSS | SVENSSON CAMILLA (SE) | 2017-06-29 | — | — | US | claimed |
| US-20160168233-A1 | CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS | NEW YORK UNIVERSITY | 2016-06-16 | — | — | US | claimed |
| US-8293788-B2 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2012-10-23 | — | — | US | claimed |
| US-20120004264-A1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ PHA.R.MA S.P.A. (IT) | 2012-01-05 | — | — | US | claimed |
| US-8039656-B2 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2011-10-18 | — | — | US | claimed |
| EP-1776336-B1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA R MA SPA RES & MFG (IT) | 2009-09-30 | — | — | EP | claimed |
| US-20090203740-A1 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPE' PHA.R.MA S.P.A (IT) | 2009-08-13 | — | — | US | claimed |
| EP-1776336-A2 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' pha.r.ma s.p.a. (IT) | 2007-04-25 | — | — | EP | claimed |
| WO-2005090295-A2 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE' PHA.R.MA S.P.A. (IT) | 2005-09-29 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203740-A1 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | CXCR2, CXCR3, MMP8 | CXCR2 1/4885CXCR1 4/4885EPHX1 1095/4885 |
| US-20200101046-A1 | IL-8 INHIBITORS FOR USE IN THE TREATMENT AND/OR PREVENTION OF BACTERIAL SECONDARY INFECTIONS | CXCL8, CXCR1, CXCR2 | CXCR2 3/4885CXCR1 2/4885EPHX1 945/4885 |
| US-20120004264-A1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CXCR2, CXCR3, MMP8 | CXCR2 1/4885CXCR1 4/4885EPHX1 1095/4885 |
| US-20250161248-A1 | Treating Chronic Myelomonocytic Leukemia with CXCL8 Receptor Inhibitors | CXCL8, CCR8, CSF3R | CXCR2 5/4885CXCR1 15/4885EPHX1 1538/4885 |
| US-20190248876-A1 | CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS | CXCR1, CXCR2, CXCR5 | CXCR2 2/4885CXCR1 1/4885EPHX1 1783/4885 |
| US-20160168233-A1 | CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS | CXCR1, CXCR2, CXCR5 | CXCR2 2/4885CXCR1 1/4885EPHX1 1783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.