Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 4/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 4/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 4/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667404 | 1.00 | P2RX3 (0.43) | P2RX3P2RX2PTGS2FAAHCTSA | |
| SCHEMBL16667326 | 0.92 | P2RX3 (0.35) | P2RX3P2RX2PTGS2FAAHCTSA | |
| SCHEMBL16667471 | 0.87 | P2RX3 (0.38) | P2RX3P2RX2 | |
| SCHEMBL16667434 | 0.87 | P2RX3 (0.38) | P2RX3P2RX2 | |
| SCHEMBL2270936 | 0.86 | P2RX3 (0.57) | P2RX3P2RX2 | |
| SCHEMBL2271106 | 0.86 | P2RX3 (0.57) | P2RX3P2RX2 | |
| SCHEMBL18036393 | 0.84 | P2RX3 (0.43) | P2RX3P2RX2FAAHCTSAALOX5AP | |
| SCHEMBL18036384 | 0.84 | P2RX3 (0.44) | P2RX3P2RX2FAAHCTSAALOX5AP | |
| SCHEMBL18036441 | 0.84 | P2RX3 (0.44) | P2RX3P2RX2FAAHCTSAALOX5AP | |
| SCHEMBL18036417 | 0.82 | P2RX3 (0.44) | P2RX3P2RX2PTGS2FAAHCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607356-B1 | Triazole-substituted arylamide derivatives and their use as P2x3 and /or P2x2/3 purinergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2015-04-29 | — | — | EP | claimed |