Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667477 | 0.86 | PIK3CA (0.49) | MTORPIK3CAPIK3R1HDAC3HDAC1 | |
| SCHEMBL1359915 | 0.82 | MTOR (0.55) | MTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL11980028 | 0.72 | PIK3CA (0.53) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL11908867 | 0.72 | PIK3CA (0.51) | MTORPIK3CAPIK3R1MERTKHDAC1 | |
| SCHEMBL11980020 | 0.71 | PIK3CA (0.46) | MTORPIK3CAPIK3R1HDAC1PIK3CD | |
| SCHEMBL11908757 | 0.71 | PIK3CA (0.49) | MTORPIK3CAPIK3R1HDAC1PIK3CD | |
| SCHEMBL16667575 | 0.71 | MTOR (0.56) | MTORPIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL11980068 | 0.71 | PIK3CA (0.51) | MTORPIK3CAPIK3R1PIK3CDPIK3C2B | |
| SCHEMBL11980022 | 0.70 | PIK3CA (0.49) | MTORPIK3CAPIK3R1HDAC1PIK3CD | |
| SCHEMBL11980065 | 0.70 | PIK3CA (0.48) | MTORPIK3CAPIK3R1HDAC1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382207-B1 | PI3K/MTOR KINASE INHIBITORS | XCOVERY HOLDING CO LLC (US) | 2015-04-29 | — | — | EP | claimed |