Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.49 |
| ▸ | MTOR | P42345 | 12/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16667455 | 0.86 | MTOR (0.46) | PIK3CAMTORPIK3R1PIK3CDHDAC3 | |
| SCHEMBL16684484 | 0.84 | MTOR (0.59) | PIK3CAMTORPIK3CD | |
| SCHEMBL1360482 | 0.82 | MTOR (0.59) | PIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL1358946 | 0.74 | MTOR (0.43) | PIK3CAMTORPIK3R1HDAC3HDAC4 | |
| SCHEMBL2599579 | 0.73 | MTOR (0.69) | PIK3CAMTOR | |
| SCHEMBL1357920 | 0.73 | MTOR (0.55) | PIK3CAMTORPIK3R1 | |
| SCHEMBL7913091 | 0.72 | MTOR (0.58) | PIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL55599 | 0.72 | PIK3CA (0.70) | PIK3CAMTORPIK3CD | |
| SCHEMBL16667575 | 0.71 | MTOR (0.56) | PIK3CAMTORPIK3R1PIK3CD | |
| SCHEMBL4996501 | 0.71 | PIK3CA (0.62) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382207-B1 | PI3K/MTOR KINASE INHIBITORS | XCOVERY HOLDING CO LLC (US) | 2015-04-29 | — | — | EP | claimed |