Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL8606637 | 0.93 | CHRM5 (0.40) | CHRM5CHRM3CA2CA12CA1 | |
| SCHEMBL628218 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL9306584 | 0.85 | SMN1; SMN2 (0.41) | SIGMAR1POLBSMN1; SMN2HSD17B10MEN1 | |
| Hydrochloric Acid SCHEMBL8083563 | 0.82 | SMN1; SMN2 (0.44) | SIGMAR1POLBSMN1; SMN2HSD17B10MEN1 | |
| Bicarbonate SCHEMBL16668577 | 0.82 | ALOX15 (0.50) | CHRM5CHRM3SIGMAR1KDM4EALDH1A1 | |
| Bicarbonate SCHEMBL16668955 | 0.79 | CXCR4 (0.47) | CHRM5CHRM3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL2007452 | 0.77 | — | — | |
| Bicarbonate SCHEMBL16668925 | 0.76 | CHRM5 (0.46) | CHRM5CHRM3CA2CA12CA1 | |
| Carbamic Acid SCHEMBL10977422 | 0.76 | ALOX15 (0.48) | CHRM5CHRM3SIGMAR1KDM4EALDH1A1 | |
| SCHEMBL1954855 | 0.74 | CXCR4 (0.63) | SIGMAR1SMN1; SMN2MEN1KMT2ACXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9956519-B2 | Absorbent for desulfurization of combustion gas and method of treating combustion gas using the same | HYUNDAI MOTOR COMPANY (KR) | 2018-05-01 | — | — | US | claimed |
| CN-104587798-A | ABSORBENT FOR DESULFURIZATION OF COMBUSTION GAS AND METHOD OF TREATING COMBUSTION GAS USING THE SAME | KIA MOTORS CORP | 2015-05-06 | — | — | CN | claimed |
| US-20150118136-A1 | ABSORBENT FOR DESULFURIZATION OF COMBUSTION GAS AND METHOD OF TREATING COMBUSTION GAS USING THE SAME | KOREA INSTITUTE OF ENERGY RESEARCH (KR) | 2015-04-30 | — | — | US | claimed |
| US-9956519-B2 | Absorbent for desulfurization of combustion gas and method of treating combustion gas using the same | HYUNDAI MOTOR COMPANY (KR) | 2018-05-01 | — | — | US | disclosed |
| CN-104587798-A | ABSORBENT FOR DESULFURIZATION OF COMBUSTION GAS AND METHOD OF TREATING COMBUSTION GAS USING THE SAME | KIA MOTORS CORP | 2015-05-06 | — | — | CN | disclosed |
| US-20150118136-A1 | ABSORBENT FOR DESULFURIZATION OF COMBUSTION GAS AND METHOD OF TREATING COMBUSTION GAS USING THE SAME | KOREA INSTITUTE OF ENERGY RESEARCH (KR) | 2015-04-30 | — | — | US | disclosed |