⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5466824 | 0.71 | — | — | |
| SCHEMBL87533 | 0.68 | — | — | |
| SCHEMBL2466527 | 0.67 | KMT2A (0.41) | — | |
| SCHEMBL17048391 | 0.67 | — | — | |
| SCHEMBL6277353 | 0.65 | — | — | |
| SCHEMBL694420 | 0.65 | — | — | |
| SCHEMBL42036 | 0.65 | — | — | |
| SCHEMBL13078874 | 0.65 | METAP2 (0.32) | — | |
| SCHEMBL1132279 | 0.64 | — | — | |
| SCHEMBL4704565 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110189192-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | claimed |
| CN-102015693-A | Compounds as ERK inhibitors | SCHERING CORP | 2011-04-13 | — | — | CN | claimed |
| EP-2260031-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | Schering Corporation (US) | 2010-12-15 | — | — | EP | claimed |
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | claimed |
| US-6489344-B1 | FOR TREATMENT DIABETES IN A HUMAN OR ANIMAL SUBJECT | CHIRON CORPORATION | 2002-12-03 | — | — | US | claimed |
| CN-102015693-B | Compounds as ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-10-29 | — | — | CN | disclosed |
| US-8716483-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-06 | — | — | US | disclosed |
| US-8658651-B2 | Compounds that are ERK inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-02-25 | — | — | US | disclosed |
| US-20120214823-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2012-08-23 | — | — | US | disclosed |
| EP-2483263-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | Schering Corporation (US) | 2012-08-08 | — | — | EP | disclosed |
| US-20110189192-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | disclosed |
| CN-102015693-A | Compounds as ERK inhibitors | SCHERING CORP | 2011-04-13 | — | — | CN | disclosed |
| WO-2011041152-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2011-04-07 | — | — | WO | disclosed |
| EP-2260031-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | Schering Corporation (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009105500-A1 | COMPOUNDS THAT ARE ERK INHIBITORS | SCHERING CORPORATION (US) | 2009-08-27 | — | — | WO | disclosed |