Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29621767 | 0.99 | GAA (0.45) | GAAHCRTR1HCRTR2ALDH1A1DRD4 | |
| Hydrochloric Acid SCHEMBL29621642 | 0.88 | NPC1 (0.45) | GAAHCRTR1HCRTR2ALDH1A1NPC1 | |
| SCHEMBL22644365 | 0.86 | KMT2A (0.52) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29621649 | 0.85 | KMT2A (0.51) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22644324 | 0.85 | GAA (0.38) | GAAALDH1A1GLAGRM4 | |
| SCHEMBL22644328 | 0.84 | AR (0.47) | BLMGRM4KDR | |
| Hydrochloric Acid SCHEMBL29621803 | 0.84 | IDO1 (0.41) | GAAALDH1A1GLANPC1RAB9A | |
| SCHEMBL22644329 | 0.83 | GRM4 (0.45) | ALDH1A1BLMGRM4SMN1; SMN2 | |
| SCHEMBL29458395 | 0.83 | GRM4 (0.45) | ALDH1A1BLMGRM4SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29621818 | 0.82 | GRM4 (0.44) | ALDH1A1BLMGRM4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10377709-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2019-08-13 | — | — | US | disclosed |
| US-20190002406-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2019-01-03 | — | — | US | disclosed |
| US-10071961-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-09-11 | — | — | US | disclosed |
| US-20180065929-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2018-03-08 | — | — | US | disclosed |
| EP-3060547-B1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-10-11 | — | — | EP | disclosed |
| US-20170158634-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-06-08 | — | — | US | disclosed |
| US-9567299-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | JANSSEN SCIENCES IRELAND UC (IE) | 2017-02-14 | — | — | US | disclosed |
| US-20160264522-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2016-09-15 | — | — | US | disclosed |
| EP-3060547-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | Janssen Sciences Ireland UC (IE) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015059212-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | JANSSEN R&D IRELAND (IE) | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002406-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | GAA 2500/4885HCRTR1 659/4885HCRTR2 1192/4885 |
| US-10071961-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HCCS, NR1H4, GLS2 | GAA 2547/4885HCRTR1 514/4885HCRTR2 996/4885 |
| US-20180065929-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, NR1H4, GLS2 | GAA 2547/4885HCRTR1 514/4885HCRTR2 996/4885 |
| US-10377709-B2 | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis B | HCCS, XDH, NR1H4 | GAA 2500/4885HCRTR1 659/4885HCRTR2 1192/4885 |
| US-20160264522-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | GAA 2500/4885HCRTR1 659/4885HCRTR2 1192/4885 |
| US-20170158634-A1 | CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B | HCCS, XDH, NR1H4 | GAA 2500/4885HCRTR1 659/4885HCRTR2 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.