Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424560 | 1.00 | ADAM10 (0.39) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| SCHEMBL13658627 | 1.00 | ADAM10 (0.39) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| Hydrochloric Acid SCHEMBL1070020 | 0.99 | ADAM10 (0.38) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| Hydrochloric Acid SCHEMBL878457 | 0.99 | ADAM10 (0.38) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| SCHEMBL8008160 | 0.89 | ADAM10 (0.39) | ADAM10ERBB2MMP1ABHD6DPP8 | |
| SCHEMBL8060188 | 0.86 | DPP8 (0.43) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| SCHEMBL8193679 | 0.86 | DPP8 (0.43) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| SCHEMBL8117948 | 0.85 | ADAM10 (0.41) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| Hydrochloric Acid SCHEMBL4584873 | 0.85 | DPP8 (0.42) | ADAM10ERBB2MMP1PIM1ABHD6 | |
| SCHEMBL8262157 | 0.84 | PIM1 (0.33) | ADAM10ERBB2MMP1PIM1ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076278-B1 | Macrocyclic HCV NS3 protease inhibitors | MERCK SHARP & DOHME (US) | 2015-05-06 | — | — | EP | disclosed |