Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.41 |
| ▸ | PDE4A | P27815 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16675010 | 1.00 | KAT2B (0.43) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL18010921 | 1.00 | KAT2B (0.43) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL29186583 | 0.84 | KAT2B (0.47) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL13696465 | 0.82 | PDE4D (0.40) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL619603 | 0.79 | CA12 (0.53) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL619604 | 0.79 | CA12 (0.53) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL15390453 | 0.78 | KAT2B (0.52) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL619682 | 0.78 | KAT2B (0.49) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL619683 | 0.78 | KAT2B (0.49) | KAT2BBAZ2BPDE4DPDE4APDE4B | |
| SCHEMBL7760101 | 0.78 | KAT2B (0.47) | KAT2BBAZ2BPDE4DPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3061747-B1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2021-04-07 | — | — | EP | disclosed |
| US-10064848-B2 | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-09-04 | — | — | US | disclosed |
| US-9914703-B2 | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-03-13 | — | — | US | disclosed |
| US-9914703-B2 | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-03-13 | — | — | US | disclosed |
| US-20180016236-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-01-18 | — | — | US | disclosed |
| US-20180016236-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-01-18 | — | — | US | disclosed |
| US-20180016236-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2018-01-18 | — | — | US | disclosed |
| EP-3061747-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2016-08-31 | — | — | EP | disclosed |
| EP-3061747-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2016-08-31 | — | — | EP | disclosed |
| US-20160244410-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2016-08-25 | — | — | US | disclosed |
| US-20160244410-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2016-08-25 | — | — | US | disclosed |
| US-20160244410-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2016-08-25 | — | — | US | disclosed |
| WO-2015058589-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | 上海恒瑞医药有限公司 | 2015-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10064848-B2 | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof | PDXK, MAP4K2, MAP3K6 | KAT2B 3546/4885BAZ2B 2496/4885PDE4D 1910/4885 |
| US-20160244410-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | PDXK, PNPO, MAP2K5 | KAT2B 3595/4885BAZ2B 2116/4885PDE4D 2769/4885 |
| US-20180016236-A1 | PYRIDIC KETONE DERIVATIVES, METHOD OF PREPARING SAME, AND PHARMACEUTICAL APPLICATION THEREOF | PDXK, MAP4K2, MAP3K6 | KAT2B 3546/4885BAZ2B 2496/4885PDE4D 1910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.