Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743595 | 0.73 | KCNA3 (0.46) | GRM5KCNA3ALDH1A1NPC1RAB9A | |
| SCHEMBL19614353 | 0.70 | CYP2B6 (0.61) | KCNA3CHRM3LMNA | |
| Ethane SCHEMBL27569967 | 0.70 | KCNA3 (0.44) | GRM5KCNA3NPC1RAB9ACHRM3 | |
| SCHEMBL4003986 | 0.68 | GRM5 (0.73) | GRM5ALDH1A1MEN1KMT2AACHE | |
| SCHEMBL1078397 | 0.68 | CES1 (0.42) | ALDH1A1CES1MGLL | |
| SCHEMBL5743652 | 0.68 | CYP2D6 (0.43) | GRM5KCNA3NPC1RAB9AMEN1 | |
| SCHEMBL1528518 | 0.67 | KCNA3 (0.41) | KCNA3ALDH1A1CHRM3LMNA | |
| SCHEMBL2493505 | 0.67 | KCNA3 (0.41) | KCNA3ALDH1A1CHRM3LMNA | |
| SCHEMBL5051767 | 0.67 | KEAP1 (0.61) | ALDH1A1CES1KEAP1NFE2L2CHRM3 | |
| SCHEMBL27817320 | 0.66 | CHRM3 (0.52) | NPC1RAB9ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488486-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | Ligand Pharmaceuticals Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046954-A1 | HEMATOPOIETIC GROWTH FACTOR MIMETIC SMALL MOLECULE COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2011-04-21 | — | — | WO | disclosed |