Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | USP14 | P54578 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667683 | 1.00 | BRD4 (0.34) | BRD4BRD2BRD3ESR1ESR2 | |
| SCHEMBL1077417 | 0.87 | ESR1 (0.38) | BRD4BRD2ESR1ESR2CYP1A2 | |
| SCHEMBL1077420 | 0.87 | ESR1 (0.38) | BRD4BRD2ESR1ESR2CYP1A2 | |
| SCHEMBL1077418 | 0.83 | PTGDR2 (0.39) | BRD4USP14CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1077413 | 0.83 | PTGDR2 (0.39) | BRD4USP14CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1667689 | 0.82 | BRD4 (0.34) | BRD4BRD2BRD3ESR1ESR2 | |
| SCHEMBL1078054 | 0.82 | PIK3CD (0.36) | BRD4USP14CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1078050 | 0.82 | PIK3CD (0.36) | BRD4USP14CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1667699 | 0.80 | BRD4 (0.36) | BRD4ESR1ESR2USP14CYP1A2 | |
| SCHEMBL1670091 | 0.80 | ESR1 (0.34) | BRD4ESR1ESR2USP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | claimed |
| WO-2011042474-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS | KARO BIO AB (SE) | 2011-04-14 | — | — | WO | disclosed |