SCHEMBL16678858

SCHEMBL16678858

[CH2]C(CC(COC(C)=O)OC(C)=O)NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 5/20 0.53
▸ MEN1 O00255 1/20 0.49
▸ ABL1 P00519 1/20 0.49
▸ LMNA P02545 1/20 0.49
▸ PKM P14618 1/20 0.49
▸ IDE P14735 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ RIN1 Q13671 1/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ CNR2 P34972 2/20 0.47
▸ CNR1 P21554 3/20 0.46
▸ CA12 O43570 3/20 0.45
▸ CA1 P00915 3/20 0.45
▸ CA2 P00918 3/20 0.45
▸ CA9 Q16790 3/20 0.45
▸ HLCS P50747 3/20 0.44
▸ CAPN1 P07384 2/20 0.44
▸ HPSE Q9Y251 1/20 0.43
▸ F2 P00734 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25306518 0.94 TDP1 (0.55) TDP1CNR2CNR1CA12CA1
SCHEMBL22712998 0.85 TDP1 (0.48) TDP1MEN1ABL1LMNAPKM
SCHEMBL22712999 0.82 TDP1 (0.48) TDP1MEN1ABL1LMNAPKM
SCHEMBL22529457 0.81 PLCD1 (0.54) TDP1CNR2CNR1CA12CA1
SCHEMBL21361151 0.81 TDP1 (0.63) TDP1MEN1ABL1LMNAPKM
SCHEMBL28352827 0.80 TDP1 (0.50) TDP1MEN1ABL1LMNAPKM
SCHEMBL15968033 0.78 F2 (0.49) TDP1MEN1ABL1LMNAPKM
SCHEMBL486814 0.78 PLCD1 (0.56) TDP1MEN1ABL1LMNAPKM
SCHEMBL12724896 0.77 TDP1 (0.68) TDP1MEN1ABL1LMNAPKM
SCHEMBL19901346 0.77 TDP1 (0.68) TDP1MEN1ABL1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10568835-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2020-02-25 — — US disclosed
US-20150125518-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. 2015-05-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10568835-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885MEN1 966/4885ABL1 4375/4885
US-20150125518-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, FABP6 TDP1 4819/4885MEN1 966/4885ABL1 4375/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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