Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 20/20 | 0.48 |
| ▸ | IKBKE | Q14164 | 13/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669856 | 0.88 | TBK1 (0.61) | TBK1IKBKE | |
| SCHEMBL12521834 | 0.81 | JAK2 (0.48) | TBK1IKBKEJAK2 | |
| SCHEMBL12274108 | 0.80 | TBK1 (0.66) | TBK1IKBKEJAK2 | |
| SCHEMBL12274545 | 0.79 | TBK1 (0.61) | TBK1IKBKE | |
| SCHEMBL1667594 | 0.78 | TBK1 (0.60) | TBK1IKBKEJAK2 | |
| SCHEMBL1667567 | 0.77 | IKBKE (0.71) | TBK1IKBKE | |
| SCHEMBL17327589 | 0.76 | TBK1 (0.57) | TBK1IKBKEJAK2 | |
| SCHEMBL1669942 | 0.76 | TBK1 (0.72) | TBK1IKBKEJAK2 | |
| SCHEMBL12274386 | 0.74 | TBK1 (0.65) | TBK1IKBKEJAK2 | |
| SCHEMBL12801141 | 0.73 | TBK1 (0.51) | TBK1IKBKEJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |