Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.65 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924831 | 0.88 | NPC1 (0.80) | NPC1PKML3MBTL1PIM3PIM2 | |
| SCHEMBL23080979 | 0.81 | KDM4E (0.54) | NPC1PKML3MBTL1PIM3PIM2 | |
| SCHEMBL23657726 | 0.76 | MAPT (0.83) | NPC1PKML3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL1520260 | 0.74 | MAPT (0.60) | NPC1PKML3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL12000239 | 0.72 | MAPT (0.61) | NPC1PKML3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL13137673 | 0.71 | MAPT (0.60) | NPC1PKML3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL1520694 | 0.68 | PIM3 (0.74) | NPC1PKML3MBTL1PIM3PIM2 | |
| SCHEMBL21563866 | 0.65 | MAPT (0.53) | NPC1PKML3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL20239461 | 0.65 | PIM3 (0.74) | NPC1PKML3MBTL1PIM3PIM2 | |
| SCHEMBL762871 | 0.65 | NPC1 (0.52) | NPC1PKML3MBTL1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509974-A1 | PYRAZOLES DERIVATIVES MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL AND METHODS FOR TREATMENT OF NON- SMALL CELL LUNG CANCER | Rhizen Pharmaceuticals S.A. (CH) | 2012-10-17 | — | — | EP | claimed |
| WO-2011042798-A1 | PYRAZOLES DERIVATIVES MODULATORS OF CALCIUM RELEASE -ACTIVATED CALCIUM CHANNEL AND METHODS FOR TREATMENT OF NON- SMALL CELL LUNG CANCER | INCOZEN THERAPEUTICS PVT. LTD. (IN) | 2011-04-14 | — | — | WO | claimed |