Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460697 | 0.86 | PIK3CG (0.51) | PIK3CGTLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL16667382 | 0.80 | PIK3CG (0.51) | PIK3CGTLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL463595 | 0.77 | PIK3CD (0.48) | PIK3CGTLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL10187722 | 0.77 | PIK3CG (0.49) | PIK3CGTLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL459270 | 0.75 | PIK3CD (0.60) | PIK3CGTLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL715647 | 0.74 | PIK3CD (0.65) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL462221 | 0.74 | PIK3CD (0.65) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL462220 | 0.74 | PIK3CD (0.65) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3R2 | |
| SCHEMBL16667320 | 0.72 | PIK3CD (0.46) | PIK3CGTLR8TLR7PIK3CDPIK3CA | |
| SCHEMBL16667453 | 0.72 | PIK3CG (0.47) | PIK3CGTLR8TLR7PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406255-B1 | 4-OXADIAZOL-2-YL-INDAZOLES AS INHIBITORS OF PI3 KINASES | GLAXO GROUP LTD (GB) | 2015-04-29 | — | — | EP | disclosed |