Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.54 |
| ▸ | MAP3K14 | Q99558 | 14/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080744 | 0.80 | TBK1 (0.54) | TBK1MAP3K14IKBKE | |
| SCHEMBL10080689 | 0.79 | TBK1 (0.53) | TBK1MAP3K14IKBKECDK2 | |
| SCHEMBL434250 | 0.79 | TBK1 (0.58) | TBK1MAP3K14IKBKECCNA2CDK2 | |
| SCHEMBL16667407 | 0.77 | TBK1 (0.51) | TBK1IKBKECDK2 | |
| SCHEMBL15307921 | 0.77 | TBK1 (0.49) | TBK1MAP3K14IKBKE | |
| SCHEMBL434196 | 0.76 | MAP3K14 (0.57) | TBK1MAP3K14CCNA2CDK2CCNA1 | |
| SCHEMBL435440 | 0.75 | TBK1 (0.65) | TBK1IKBKECCNA2CDK2CCNA1 | |
| SCHEMBL432472 | 0.75 | TBK1 (0.65) | TBK1CCNA2CDK2CCNA1 | |
| SCHEMBL459048 | 0.75 | TBK1 (0.73) | TBK1MAP3K14IKBKECCNA2CDK2 | |
| SCHEMBL10080741 | 0.75 | TBK1 (0.61) | TBK1MAP3K14IKBKECCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595964-B1 | Pyrimidine compounds as inhibitors of protein kinases IKK epsilon and/or TBK-1, processes for their preparation, and pharmaceutical compositions containing them | DOMAINEX LTD (GB) | 2015-04-29 | — | — | EP | disclosed |