Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 9/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.32 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456240 | 1.00 | KAT2B (0.36) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL10742569 | 1.00 | KAT2B (0.36) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL13881962 | 1.00 | KAT2B (0.36) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL3975067 | 1.00 | KAT2B (0.36) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL11456241 | 1.00 | KAT2B (0.36) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL10742576 | 1.00 | KAT2B (0.36) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL20095910 | 0.98 | KAT2B (0.35) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL11457010 | 0.98 | KAT2B (0.35) | KAT2BLATS1IKZF2IKZF1 | |
| SCHEMBL11461639 | 0.95 | KAT2B (0.36) | KAT2BLATS1 | |
| SCHEMBL11461640 | 0.95 | KAT2B (0.36) | KAT2BLATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294732-B1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES INC (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2016186967-A1 | BENZIMIDAZOLE AND IMADAZOPYRIDINE CARBOXIMIDAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | GILEAD SCIENCES, INC. (US) | 2016-11-24 | — | — | WO | disclosed |
| EP-1548121-B1 | Physiologically active substances | EISAI R&D MAN CO LTD (JP) | 2015-04-29 | — | — | EP | disclosed |