Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684606 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KDM4EL3MBTL1MAPTNPC1 | |
| SCHEMBL16693146 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KDM4EL3MBTL1MAPTNPC1 | |
| SCHEMBL16684706 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1MAPTPKM | |
| SCHEMBL16684707 | 0.80 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1MAPTPKM | |
| SCHEMBL16686997 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4EL3MBTL1MAPTPKM | |
| SCHEMBL16686996 | 0.80 | ALDH1A1 (0.40) | ALDH1A1KDM4EL3MBTL1MAPTPKM | |
| SCHEMBL16684571 | 0.77 | PTPN1 (0.46) | ALDH1A1KDM4ERAB9ASMN1; SMN2KMT2A | |
| SCHEMBL2163592 | 0.73 | SMN1; SMN2 (0.52) | ALDH1A1KDM4EL3MBTL1MAPTNPC1 | |
| SCHEMBL13859186 | 0.73 | SMN1; SMN2 (0.52) | ALDH1A1KDM4EL3MBTL1MAPTNPC1 | |
| SCHEMBL2163596 | 0.73 | SMN1; SMN2 (0.52) | ALDH1A1KDM4EL3MBTL1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066371-A1 | SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |