Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16695100 | 1.00 | NOTUM (0.47) | NOTUMSMN1; SMN2PDK2NPC1RAB9A | |
| SCHEMBL16695146 | 1.00 | NOTUM (0.47) | NOTUMSMN1; SMN2PDK2NPC1RAB9A | |
| SCHEMBL16695240 | 0.87 | NOTUM (0.62) | NOTUM | |
| SCHEMBL16695078 | 0.84 | NOTUM (0.43) | NOTUMPDK2 | |
| SCHEMBL16695065 | 0.84 | NOTUM (0.43) | NOTUMPDK2 | |
| SCHEMBL16695411 | 0.83 | MAPT (0.47) | NOTUMSMN1; SMN2PDK2NPC1RAB9A | |
| SCHEMBL30263140 | 0.77 | NOTUM (0.76) | NOTUM | |
| SCHEMBL16695120 | 0.76 | NOTUM (0.54) | NOTUM | |
| SCHEMBL2636602 | 0.76 | NOTUM (0.54) | NOTUM | |
| SCHEMBL16695072 | 0.76 | DPP4 (0.52) | NOTUMSMN1; SMN2PDK2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-A1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BioMarin Pharmaceutical Inc. (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015065937-A1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARMACEUTICAL INC. (US) | 2015-05-07 | — | — | WO | disclosed |