Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684695 | 1.00 | APP (0.48) | APPPRMT1ACHEKDM4EALDH1A1 | |
| SCHEMBL16693152 | 0.86 | APP (0.48) | APPPRMT1ACHEKDM4EHPGD | |
| SCHEMBL16684587 | 0.86 | APP (0.48) | APPPRMT1ACHEKDM4EHPGD | |
| SCHEMBL16684573 | 0.77 | CYP2A6 (0.58) | APPPRMT1ACHEKDM4EALDH1A1 | |
| SCHEMBL16693057 | 0.77 | CYP2A6 (0.58) | APPKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL533466 | 0.77 | CYP2A6 (0.58) | APPKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6488493 | 0.76 | KMT2A (0.46) | PRMT1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6488496 | 0.76 | KMT2A (0.46) | PRMT1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL20559600 | 0.73 | APP (0.43) | APPACHEF2RL3PGR | |
| SCHEMBL20559602 | 0.73 | APP (0.43) | APPACHEF2RL3PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066371-A1 | SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |
| WO-2015066371-A1 | SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |