Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16684587 | 1.00 | APP (0.48) | APPCA12CA1CA2CA9 | |
| SCHEMBL16684694 | 0.86 | APP (0.48) | APPCYP2A6KDM4EACHEPRMT1 | |
| SCHEMBL16684695 | 0.86 | APP (0.48) | APPCYP2A6KDM4EACHEPRMT1 | |
| SCHEMBL23469130 | 0.77 | APP (0.55) | APPCA12CA1CA2CA9 | |
| SCHEMBL118925 | 0.77 | CYP2A6 (0.62) | APPCA12CA1CA2CA9 | |
| SCHEMBL16693057 | 0.77 | CYP2A6 (0.58) | APPCA12CA1CA9CYP2A6 | |
| SCHEMBL533466 | 0.77 | CYP2A6 (0.58) | APPCA12CA1CA9CYP2A6 | |
| SCHEMBL16693050 | 0.74 | MAPT (0.35) | HPGDGFERSMN1; SMN2MAPT | |
| SCHEMBL6488293 | 0.71 | ALOX15 (0.48) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL6488298 | 0.71 | ALOX15 (0.48) | CA12CA1CA2CA9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066371-A1 | SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF α-7-NICOTINIC ACETYLCHOLINE RECEPTORS | FORUM PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |