Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.58 |
| ▸ | CNR2 | P34972 | 1/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984446 | 0.79 | NOTUM (0.77) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL447187 | 0.75 | NOTUM (1.00) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL26932396 | 0.73 | NOTUM (0.73) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL26691209 | 0.73 | NOTUM (0.73) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL16684905 | 0.73 | NOTUM (0.58) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL16684978 | 0.72 | NOTUM (0.47) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL15543771 | 0.71 | CNR2 (1.00) | NOTUMCNR2BIRC2 | |
| SCHEMBL27565401 | 0.71 | NOTUM (0.69) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL27527695 | 0.69 | NOTUM (0.57) | NOTUMCNR2HTR3EHTR3BHTR3A | |
| SCHEMBL28008763 | 0.68 | NOTUM (0.63) | NOTUMCNR2HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066344-A1 | 5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE | ARENA PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | WO | disclosed |