SCHEMBL7984446

SCHEMBL7984446

CC1(C)CN(C(=O)O)c2ccccc21

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 3/20 0.77
CNR2 P34972 1/20 0.61
BIRC2 Q13490 1/20 0.51
HTR3E A5X5Y0 1/20 0.50
HTR3B O95264 1/20 0.50
HTR3A P46098 1/20 0.50
HTR3D Q70Z44 1/20 0.50
HTR3C Q8WXA8 1/20 0.50
ROCK1 Q13464 1/20 0.45
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
PIK3CD O00329 1/20 0.42
CYP3A4 P08684 1/20 0.42
AKT1 P31749 1/20 0.42
PIK3CA P42336 1/20 0.42
PIK3CB P42338 1/20 0.42
PIK3CG P48736 1/20 0.42
P2RY1 P47900 1/20 0.42
MEN1 O00255 1/20 0.42
ADRB2 P07550 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL447187 0.87 NOTUM (1.00) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL26691209 0.86 NOTUM (0.73) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL26932396 0.86 NOTUM (0.73) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL27527695 0.84 NOTUM (0.57) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL27565401 0.83 NOTUM (0.69) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL31378004 0.82 NOTUM (0.54) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL28008763 0.79 NOTUM (0.63) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL16684905 0.79 NOTUM (0.58) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL16685102 0.79 NOTUM (0.58) NOTUMCNR2BIRC2HTR3EHTR3B
SCHEMBL30694937 0.77 NOTUM (0.49) NOTUMCNR2BIRC2ROCK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6274594-B1 ANTICONVULSANTS, ANALGESICS; NERUOPATHIC, CANCER AND DENTAL PAIN; SMITHKLINE BEECHAM P.L.C. (GB) 2001-08-14 US claimed
EP-1032570-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM PLC (GB) 2000-09-06 EP claimed
WO-2000008022-A1 UREA DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2000-02-17 WO claimed
WO-1999025709-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM P.L.C. (GB) 1999-05-27 WO claimed
US-6274594-B1 ANTICONVULSANTS, ANALGESICS; NERUOPATHIC, CANCER AND DENTAL PAIN; SMITHKLINE BEECHAM P.L.C. (GB) 2001-08-14 US disclosed
EP-1032570-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM PLC (GB) 2000-09-06 EP disclosed
WO-2000008022-A1 UREA DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2000-02-17 WO disclosed
WO-1999025709-A1 ISOQUINOLINE DERIVATIVES AND THEIR THERAPEUTICAL USE SMITHKLINE BEECHAM P.L.C. (GB) 1999-05-27 WO disclosed