Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 5/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13412435 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1LMNAAPPCNR1 | |
| SCHEMBL30763075 | 0.78 | HRH4 (0.45) | SMN1; SMN2ALDH1A1LMNAAPPCNR1 | |
| SCHEMBL1993092 | 0.76 | PDE2A (0.47) | SMN1; SMN2ALDH1A1LMNAAPPCNR1 | |
| SCHEMBL20980464 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1LMNAAPPCNR1 | |
| SCHEMBL9987222 | 0.75 | CNR1 (0.44) | SMN1; SMN2ALDH1A1LMNAAPPCNR1 | |
| SCHEMBL15595369 | 0.74 | APP (0.54) | SMN1; SMN2ALDH1A1LMNAAPPMAOB | |
| SCHEMBL1259197 | 0.74 | NPC1 (0.55) | SMN1; SMN2ALDH1A1APPMAOBNPC1 | |
| SCHEMBL23093183 | 0.74 | CCR4 (0.40) | ALDH1A1 | |
| SCHEMBL24316810 | 0.74 | CSF1R (0.52) | ALDH1A1LMNAAPPCNR1CNR2 | |
| SCHEMBL31381827 | 0.74 | CNR2 (0.46) | SMN1; SMN2ALDH1A1LMNAAPPCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015066697-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |