Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1668765 | 0.95 | KDM4E (0.40) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL1668410 | 0.92 | KDM4E (0.49) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL12198265 | 0.90 | KDM4E (0.41) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL1668262 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL12198321 | 0.86 | KDM4E (0.52) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL1668516 | 0.85 | LMNA (0.38) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL1668787 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1LMNAKMT2ARORC | |
| SCHEMBL1671394 | 0.82 | EPHX2 (0.46) | KDM4EALDH1A1LMNAKCNH2EPHX2 | |
| SCHEMBL2511739 | 0.81 | LMNA (0.40) | KDM4ELMNAKMT2ARORCEPHX2 | |
| SCHEMBL1668633 | 0.81 | LMNA (0.38) | KDM4EALDH1A1LMNAKMT2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486033-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2012-08-15 | — | — | EP | claimed |
| WO-2011044001-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2011-04-14 | — | — | WO | claimed |