Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22372185 | 0.88 | MAPK14 (0.49) | MAPK14HTR4HTR6TDP1CNR1 | |
| SCHEMBL31128412 | 0.77 | CHRNB2 (0.37) | HTR6HPGDKDM4EGRM4 | |
| SCHEMBL22372064 | 0.71 | HPGD (0.44) | HPGDKDM4E | |
| SCHEMBL14284220 | 0.71 | GNRHR (0.41) | MAPK14HTR4GNRHRGSK3BTDP1 | |
| SCHEMBL1724542 | 0.70 | TDP1 (0.44) | GNRHRTDP1 | |
| SCHEMBL12615476 | 0.70 | TDP1 (0.44) | GNRHRHPGDTDP1 | |
| SCHEMBL1724543 | 0.70 | TDP1 (0.44) | GNRHRTDP1 | |
| SCHEMBL2428932 | 0.70 | NPC1 (0.45) | KDM4E | |
| SCHEMBL20855733 | 0.70 | MAPK14 (0.45) | MAPK14GNRHRTDP1 | |
| SCHEMBL20855734 | 0.70 | MAPK14 (0.45) | MAPK14GNRHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488491-A1 | NOVEL N-SUBSTITUTED-PYRROLIDINES AS INHIBITORS OF MDM2-P-53 INTERACTIONS | F. Hoffmann-La Roche AG (CH) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045257-A1 | NOVEL N-SUBSTITUTED-PYRROLIDINES AS INHIBITORS OF MDM2-P-53 INTERACTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-21 | — | — | WO | disclosed |