Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 19/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | AKT1 | P31749 | 1/20 | 0.65 |
| ▸ | AKT2 | P31751 | 1/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16689794 | 0.91 | RPS6KB1 (1.00) | RPS6KB1ROCK2AKT1AKT2KCNH2 | |
| SCHEMBL14787775 | 0.91 | RPS6KB1 (1.00) | RPS6KB1ROCK2AKT1AKT2KCNH2 | |
| SCHEMBL28392827 | 0.91 | RPS6KB1 (0.87) | RPS6KB1ROCK2AKT1AKT2KCNH2 | |
| SCHEMBL14787862 | 0.89 | RPS6KB1 (1.00) | RPS6KB1 | |
| SCHEMBL14787744 | 0.88 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL14787917 | 0.87 | RPS6KB1 (1.00) | RPS6KB1ROCK2AKT1AKT2AKT3 | |
| SCHEMBL19200856 | 0.86 | RPS6KB1 (0.81) | RPS6KB1 | |
| SCHEMBL14787774 | 0.85 | RPS6KB1 (1.00) | RPS6KB1ROCK2AKT1AKT2KCNH2 | |
| SCHEMBL14787678 | 0.85 | RPS6KB1 (1.00) | RPS6KB1ROCK2AKT1AKT2KCNH2 | |
| SCHEMBL14787903 | 0.83 | RPS6KB1 (1.00) | RPS6KB1ROCK2AKT1AKT2AKT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170217905-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| US-20170217905-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| US-9662330-B2 | Aminopyrimidine derivatives for use as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2017-05-30 | — | — | US | disclosed |
| US-9662330-B2 | Aminopyrimidine derivatives for use as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2017-05-30 | — | — | US | disclosed |
| US-20160184308-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-20160184308-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2016-06-30 | — | — | US | disclosed |
| US-9321760-B2 | Aminopyrimidine derivatives for use as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2016-04-26 | — | — | US | disclosed |
| US-9321760-B2 | Aminopyrimidine derivatives for use as modulators of kinase activity | MERCK PATENT GMBH (DE) | 2016-04-26 | — | — | US | disclosed |
| US-20150126484-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2015-05-07 | — | — | US | disclosed |
| US-20150126484-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | MERCK PATENT GMBH (DE) | 2015-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217905-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | CDK6, TK1, MAP3K19 | RPS6KB1 165/4885ROCK2 896/4885AKT1 173/4885 |
| US-20150126484-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | CDK6, TK1, MAP3K19 | RPS6KB1 165/4885ROCK2 896/4885AKT1 173/4885 |
| US-20160184308-A1 | AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY | CDK6, TK1, MAP3K19 | RPS6KB1 165/4885ROCK2 896/4885AKT1 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.