SCHEMBL1668992

SCHEMBL1668992

N#Cc1cccc(-c2nc3ccc(N4CCN5CCCCCCCCCCCCCCCCCCCCCC4CC5)cc3c(=O)n2C2CCC2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
CYP1A2 P05177 3/20 0.38
CYP3A4 P08684 3/20 0.38
CASP1 P29466 3/20 0.38
CASP7 P55210 3/20 0.38
CYP2C9 P11712 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TP53 P04637 1/20 0.38
HPGD P15428 1/20 0.38
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CHRNA7 P36544 2/20 0.38
GAA P10253 1/20 0.38
ALOX15 P16050 1/20 0.38
USP2 O75604 2/20 0.38
HIF1A Q16665 2/20 0.38
MEN1 O00255 1/20 0.38
GLA P06280 1/20 0.38
KMT2A Q03164 1/20 0.38
CLK4 Q9HAZ1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6887906 0.97 CHRNA7 (0.40) ALDH1A1CYP1A2CYP3A4CASP1CASP7
SCHEMBL1668780 0.90 HRH3 (0.39) ALDH1A1CYP1A2CYP3A4CASP1CASP7
SCHEMBL6887263 0.85 CHRNA7 (0.43) ALDH1A1HPGDTSHRSMN1; SMN2CHRNA7
SCHEMBL6888190 0.85 CHRNA7 (0.47) ALDH1A1CYP3A4CYP2C9CHRNA7GAA
SCHEMBL11905048 0.85 CHRNA7 (0.41) ALDH1A1CYP1A2CYP3A4CASP1CASP7
SCHEMBL6888927 0.84 KDM4E (0.43) CYP1A2CYP3A4CHRNA7GAAALOX15
SCHEMBL1668821 0.84 HRH3 (0.39) ALDH1A1CYP1A2CYP3A4CASP1CASP7
SCHEMBL1669105 0.84 TLR7 (0.35) ALDH1A1CYP1A2CYP3A4CASP1CASP7
SCHEMBL6886841 0.81 CHRNA7 (0.45) ALDH1A1HPGDTSHRSMN1; SMN2CHRNA7
SCHEMBL1670129 0.81 GAA (0.42) CHRNA7GAAALOX15MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488520-A1 CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR MSD Oss B.V. (NL) 2012-08-22 EP disclosed
WO-2011045258-A1 CONDENSED AZINE - DERIVATIVES FOR THE TREATMENT OF DISEASES RELATED TO THE ACETYLCHOLINE RECEPTOR N.V. ORGANON (NL) 2011-04-21 WO disclosed