Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 11/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | SMO | Q99835 | 2/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | SORD | Q00796 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785843 | 0.86 | HRH4 (0.57) | HRH4LSSHRH3CARM1PRMT6 | |
| SCHEMBL22932938 | 0.81 | OGA (0.52) | HRH4LSSHRH3SORD | |
| SCHEMBL17637741 | 0.81 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL28791452 | 0.81 | HRH4 (0.69) | HRH4HRH3 | |
| SCHEMBL16684774 | 0.80 | HRH3 (0.69) | HRH4LSSHRH3SORD | |
| SCHEMBL17637738 | 0.79 | HRH4 (0.53) | HRH4HRH3GPBAR1 | |
| Hydrochloric Acid SCHEMBL2272733 | 0.78 | HRH3 (0.67) | HRH4LSSHRH3SORD | |
| Hydrochloric Acid SCHEMBL16684891 | 0.78 | HRH3 (0.67) | HRH4LSSHRH3SORD | |
| SCHEMBL12440254 | 0.77 | HRH3 (0.45) | HRH4LSSHRH3SORD | |
| SCHEMBL24799135 | 0.77 | SORD (0.48) | HRH4LSSHRH3GPBAR1SORD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015138689-A1 | FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015066696-A1 | FUSED MORPHLINOPYRIMIDINES AND METHODS OF USE THEREOF | FORUM PHARMACEUTICALS INC. (US) | 2015-05-07 | — | — | WO | disclosed |