Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 7/20 | 0.77 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | KHK | P50053 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261943 | 0.93 | DRD4 (0.77) | DRD4DRD3DRD2POLBSIGMAR1 | |
| SCHEMBL6031812 | 0.87 | DRD4 (1.00) | DRD4DRD3DRD2KDM4EALDH1A1 | |
| SCHEMBL27371894 | 0.85 | DRD4 (0.71) | DRD4DRD3DRD2POLBKDM4E | |
| SCHEMBL1509470 | 0.83 | POLB (0.63) | DRD4DRD3DRD2POLBKHK | |
| SCHEMBL28269086 | 0.83 | LSS (0.66) | POLBKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL27371885 | 0.83 | USP2 (0.61) | DRD2KDM4ESIGMAR1 | |
| SCHEMBL8312103 | 0.82 | DRD4 (0.70) | DRD4DRD3DRD2POLBKDM4E | |
| SCHEMBL5629449 | 0.82 | DRD4 (0.70) | DRD4DRD3DRD2POLBKHK | |
| SCHEMBL4579770 | 0.82 | POLB (0.61) | DRD4DRD2POLBKDM4EALDH1A1 | |
| SCHEMBL27371936 | 0.82 | ALDH1A1 (0.57) | DRD4DRD3DRD2POLBKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313096-A1 | NEW COMPOUNDS V | AstraZeneca AB (Publ) (SE) | 2011-04-27 | — | — | EP | claimed |
| WO-2009147211-A1 | NEW COMPOUNDS V | BIOVITRUM AB (PUBL) (SE) | 2009-12-10 | — | — | WO | claimed |