Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 20/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18203310 | 0.89 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1 | |
| SCHEMBL11908527 | 0.87 | HSP90AA1 (0.52) | HSP90AA1HSP90AB1 | |
| SCHEMBL11909836 | 0.87 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203431 | 0.86 | ERBB2 (0.46) | HSP90AA1HSP90AB1 | |
| SCHEMBL11909679 | 0.86 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1 | |
| SCHEMBL1669714 | 0.83 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1 | |
| SCHEMBL18203423 | 0.82 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1 | |
| SCHEMBL20853473 | 0.82 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL11908450 | 0.79 | ERBB2 (0.54) | HSP90AA1HSP90AB1 | |
| SCHEMBL1670456 | 0.78 | HSP90AB1 (0.57) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3091019-B1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-04-03 | — | — | EP | disclosed |
| EP-3091019-A2 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2016-11-09 | — | — | EP | disclosed |
| EP-2486039-A1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044394-A1 | PURINE DERIVATIVES USEFUL AS HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2011-04-14 | — | — | WO | disclosed |