Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | LGALS8 | O00214 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LRAT | O95237 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23865565 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL23705072 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL11163399 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL23705099 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL24256554 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL24256226 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL24256547 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL23346141 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL22899188 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 | |
| SCHEMBL17054750 | 1.00 | LMNA (0.47) | LMNAKDM4EALOX15LGALS8HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9163239-B2 | Compositions and methods for modulating apolipoprotein C-III expression | ISIS PHARMACEUTICALS, INC. (US) | 2015-10-20 | — | — | US | disclosed |
| US-20150126719-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2015-05-07 | — | — | US | disclosed |