SCHEMBL16696129

SCHEMBL16696129

CS(=O)(=O)CCCn1c(Cn2c(=O)n(C3CC3)c3ccncc32)nc(=O)c2ccccc21

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.61
TNKS O95271 1/20 0.38
CYP2D6 P10635 6/20 0.38
MAOA P21397 4/20 0.36
MAOB P27338 4/20 0.36
ACHE P22303 1/20 0.36
C5AR1 P21730 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16696138 0.92 CYP3A4 (0.49) CYP3A4CYP2D6C5AR1
SCHEMBL16696084 0.90 CYP3A4 (0.53) CYP3A4
SCHEMBL9978085 0.87 CYP3A4 (0.59) CYP3A4TNKSCYP2D6
SCHEMBL16696055 0.87 CYP3A4 (0.80) CYP3A4TNKSCYP2D6MAOAMAOB
SCHEMBL16696161 0.85 CYP3A4 (0.62) CYP3A4TNKSCYP2D6MAOAMAOB
SCHEMBL16696088 0.85 CYP3A4 (0.59) CYP3A4TNKSCYP2D6C5AR1
SCHEMBL16696101 0.85 CYP3A4 (0.61) CYP3A4TNKSCYP2D6C5AR1
SCHEMBL16696165 0.85 CYP3A4 (0.61) CYP3A4TNKSCYP2D6C5AR1
SCHEMBL16696030 0.84 CYP3A4 (0.45) CYP3A4CYP2D6C5AR1
SCHEMBL16696062 0.83 CYP3A4 (0.62) CYP3A4TNKSCYP2D6MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015065336-A1 RESPIRATORY SYNCYTIAL VIRUS INHIBITORS MEDIVIR AB (SE) 2015-05-07 WO disclosed