Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 17/20 | 0.78 |
| ▸ | JAK2 | O60674 | 7/20 | 0.78 |
| ▸ | IKBKE | Q14164 | 6/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12275278 | 1.00 | TBK1 (0.78) | TBK1JAK2IKBKEJAK3 | |
| SCHEMBL1667100 | 0.95 | TBK1 (0.71) | TBK1JAK2IKBKE | |
| SCHEMBL1667619 | 0.94 | TBK1 (0.68) | TBK1JAK2IKBKEJAK3 | |
| SCHEMBL12275973 | 0.92 | TBK1 (0.65) | TBK1JAK2IKBKE | |
| SCHEMBL20918397 | 0.91 | TBK1 (0.80) | TBK1JAK2 | |
| SCHEMBL29772697 | 0.90 | TBK1 (0.76) | TBK1JAK2IKBKE | |
| SCHEMBL1667556 | 0.90 | TBK1 (0.76) | TBK1JAK2IKBKE | |
| SCHEMBL1667172 | 0.89 | TBK1 (0.69) | TBK1JAK2IKBKE | |
| SCHEMBL11962937 | 0.88 | TBK1 (0.61) | TBK1JAK2IKBKEJAK3 | |
| SCHEMBL1667659 | 0.88 | TBK1 (0.70) | TBK1JAK2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | claimed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| EP-2488503-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | Myrexis, Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |